Blind rose through the youth ranks at Ajax, becoming a regular after a loan to Groningen, and won four consecutive Eredivisie titles with the club. In September 2014, he transferred to Manchester United for £13.8million.

His first goal for the club came on 20 October 2014, a 20-yard strike that earned United a 2–2 draw at West Bromwich Albion.

On 12 September 2015, he scored his first goal of that season in a 3–1 win against Liverpool at Old Trafford, also being named man of the match for his performance.

He began the 2016–17 Premier League season as first choice center-back alongside Chris Smalling, however he lost his place in the team following a return to form of Phil Jones and Marcos Rojo.

He however worked his way back to the first team, but featured mostly at left back replacing first choice left back Luke Shaw.

He scored his first goal of the season against Sunderland on Boxing Day, charging into the box to connect with a pass from Zlatan Ibrahimović and finishing low into the bottom corner.